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In this context, multitargeted treatment of opioid receptors can improve the drug tolerance and safety profile [55,56], and previous studies have shown that simultaneous activation of MOR and DOR with bivalent agonist ligands delivers potent analgesia in experimental NP [57,58,59]

Like G1, the G2 risk variant has two amino acids (N388del and Y389del) deleted at the same APOL1 position (214)

Accordingly, glutamine starvation reduces the glutathione pool of transformed cells [33,53]

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